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KMID : 0372919910120010057
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Journal of Biomedical Engineering Research
1991 Volume.12 No. 1 p.57 ~ p.62
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Synthesis of Poly-N5 -(3-hydroxypropyl glutamine)/Poly(ethylene glycol) block Copolymer Hydrogel and Its Application to the Artificial Skin
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Sung Yong-Kiel
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Abstract
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ABA type block copolymers composed of poly(T-benzyl L-glutamate) (PBLG) as the A component and poly (ethylene glycol) as the B component were obtained by polymerization of T-benzyl L-gletamate N -carboxyanhydride, initiated by amino groups at both ends of poly(ethylene glycol) . From circular dichroism measurements in ethylene dichloride solution as well as from infrared spectTa measurements in solid state, it was found that the polypep- tide block exists in the a-helical conformation, as in PBLG homopolymer. Poly -Ns (3-hydroxypropyl glutamine) (PHPG)/poly(ethylene glycol)block copolymer hydrogel was obtained by the treatment of PBLG/PBG block copolymer with the mixture of 3-ammine-1-propanol and diamlnooctane. The water content of PHPG/PEG block copolymer hydrogel was about 80wt% when the concentration of crosslinking agent was below 5 mole % per polymer.
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